The following study was conducted by Scientists from Centre for Blood Research, Life Sciences Institute, The University of British Columbia, Vancouver, BC, Canada; Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, BC, Canada; Centre for High Throughput Biology, Michael Smith Laboratories, The University of British Columbia, Vancouver, BC, Canada; Inter University Centre for Biomedical Research & Super Speciality Hospital, Mahatma Gandhi University Campus at Thalappady, Kottayam, Kerala, India; Department of Chemistry, The University of British Columbia, Vancouver, BC, Canada; School of Biomedical Engineering, The University of British Columbia, Vancouver, BC, Canada. Study is published in Nature Communications Journal as detailed below
Nature Communications; Volume 11, Article Number: 3048 (2020)
Blood Circulation of Soft Nanomaterials is governed by Dynamic Remodeling of Protein Opsonins at Nano-Biointerface
Abstract
Nanomaterials in the blood must mitigate the immune response to have a prolonged vascular residency in vivo. The composition of the protein corona that forms at the nano-biointerface may be directing this, however, the possible correlation of corona composition with blood residency is currently unknown. Here‚ we report a panel of new soft single molecule polymer nanomaterials (SMPNs) with varying circulation times in mice (t1/2β ~ 22 to 65 h) and use proteomics to probe protein corona at the nano-biointerface to elucidate the mechanism of blood residency of nanomaterials. The composition of the protein opsonins on SMPNs is qualitatively and quantitatively dynamic with time in circulation. SMPNs that circulate longer are able to clear some of the initial surface-bound common opsonins, including immunoglobulins, complement, and coagulation proteins. This continuous remodelling of protein opsonins may be an important decisive step in directing elimination or residence of soft nanomaterials in vivo.
Source:
Nature Communications
URL: https://www.nature.com/articles/s41467-020-16772-x
Citation:
Abbina, S., L. E. Takeuchi, et al. (2020). “Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nano-biointerface.” Nature Communications 11(1): 3048.
