The following study was conducted by Scientists from Center for Evolutionary Hologenomics, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark; Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU), Leioa, Spain; Department of Health Technology, Section for Bioinformatics, Technical University of Denmark, Kongens Lyngby, Denmark; Norwegian University of Science and Technology, University Museum, Trondheim, Norway. Study is published in iScience Journal – Cell Press Publishing as detailed below.
iScience Journal – Cell Press Publishing (2020)
Holo-omics: Integrated Host-Microbiota Multi-omics for Basic and Applied Biological Research
Highlights
- Complex organisms are shaped by the interactions with their associated microbiota
- Exploring these interactions are essential to understand complex animal systems
- The holo-omic approach combine multi-omic data from both host and microbiota domain
- This approach are likely to make way for new discoveries in various field of research
Summary
From ontogenesis to homeostasis, the phenotypes of complex organisms are shaped by the bi-directional interactions between the host organisms and their associated microbiota. Current technology can reveal many such interactions, by combining multi-omic data from both hosts and microbes. However, exploring the full extent of these interactions requires careful consideration of study design for the efficient generation and optimal integration of data derived from (meta)genomics, (meta)transcriptomics, (meta)proteomics, and (meta)metabolomics. In this perspective, we introduce the holo-omic approach that incorporates multi-omic data from both host and microbiota domains, to untangle the interplay between the two. We revisit the recent literature on biomolecular host-microbe interactions, and discuss the implementation and current limitations of the holo-omic approach. We anticipate that the application of this approach can contribute to opening new research avenues and discoveries in biomedicine, biotechnology, agri- and aquacultural sciences, nature conservation as well as basic ecological and evolutionary research.
Source:
iScience Journal – Cell Press Publishing
URL: https://www.cell.com/iscience/fulltext/S2589-0042(20)30604-0
Citation:
Nyholm L, Koziol A, Marcos S, et al. Holo-Omics: Integrated Host-Microbiota Multi-omics for Basic and Applied Biological Research. iScience. 2020;23 (8):101414. doi:10.1016/j.isci.2020.101414
