The following study was conducted by Scientists from Department of Protein Science, KTH-Royal Institute of Technology, Stockholm, Sweden; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; Region Västra Götaland, Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden;Region Västra Götaland, Department of Clinical Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. Study is published in Nature Communications Journal as detailed below.
Nature Communications; Volume 12, Article Number: 2493 (2021)
Next Generation Plasma Proteome Profiling to Monitor Health and Disease
Abstract
The need for precision medicine approaches to monitor health and disease makes it important to develop sensitive and accurate assays for proteome profiles in blood. Here, we describe an approach for plasma profiling based on proximity extension assay combined with next generation sequencing. First, we analyze the variability of plasma profiles between and within healthy individuals in a longitudinal wellness study, including the influence of genetic variations on plasma levels. Second, we follow patients newly diagnosed with type 2 diabetes before and during therapeutic intervention using plasma proteome profiling. The studies show that healthy individuals have a unique and stable proteome profile and indicate that a panel of proteins could potentially be used for early diagnosis of diabetes, including stratification of patients with regards to response to metformin treatment. Although validation in larger cohorts is needed, the analysis demonstrates the usefulness of comprehensive plasma profiling for precision medicine efforts.
Source:
Nature Communications
URL: https://www.nature.com/articles/s41467-021-22767-z
Citation:
Zhong, W., Edfors, F., Gummesson, A. et al. Next generation plasma proteome profiling to monitor health and disease. Nat Commun 12, 2493 (2021). https://doi.org/10.1038/s41467-021-22767-z
