The following study was conducted by Scientists from School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China; State Key Laboratory for Oncogenes and Related Genes, Division of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Laboratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China; Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan; Department of Chemistry, Stanford University, Stanford, CA, USA. Study is published in Nature Communications as detailed below.
Nature Communications; Volume 11, Article Number: 1654; (2020)
Diagnosis and Prognosis of Myocardial Infarction on a Plasmonic Chip
Abstract
Cardiovascular diseases lead to 31.5% of deaths globally, and particularly myocardial infarction (MI) results in 7.4 million deaths per year. Diagnosis of MI and monitoring for prognostic use are critical for clinical management and biomedical research, which require advanced tools with accuracy and speed. Herein, we developed a plasmonic gold nano-island (pGold) chip assay for diagnosis and monitoring of MI. On-chip microarray analysis of serum biomarkers (e.g., cardiac troponin I) afforded up to 130-fold enhancement of near-infrared fluorescence for ultra-sensitive and quantitative detection within controlled periods, using 10 μL of serum only. The pGold chip assay achieved MI diagnostic sensitivity of 100% and specificity of 95.54%, superior to the standard chemiluminescence immunoassay in cardiovascular clinics. Further, we monitored biomarker concentrations regarding percutaneous coronary intervention for prognostic purpose. Our work demonstrated a designed approach using plasmonic materials for enhanced diagnosis and monitoring for prognostic use towards point-of-care testing.
Source:
Nature Communications
URL: https://www.nature.com/articles/s41467-020-15487-3
Citation:
Xu, W., L. Wang, et al. (2020). “Diagnosis and prognosis of myocardial infarction on a plasmonic chip.” Nature Communications 11(1): 1654.
