The following study was conducted by Scientists from Division of Pediatric Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA, USA; Department of Pharmacology & Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA, USA; Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA, USA; Southeast Louisiana Veterans Health Care Systems, New Orleans, LA, USA. Study is published in Nature Communications Journal as detailed below.
Nature Communications; Volume 11, Article Number: 5165 (2020)
ACE2 Mouse Models: A Toolbox for Cardiovascular and Pulmonary Research
Abstract
Angiotensin-converting enzyme 2 (ACE2) has been identified as the host entry receptor for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the COVID-19 pandemic. ACE2 is a regulatory enzyme of the renin-angiotensin system and has protective functions in many cardiovascular, pulmonary and metabolic diseases. This review summarizes available murine models with systemic or organ-specific deletion of ACE2, or with overexpression of murine or human ACE2. The purpose of this review is to provide researchers with the genetic tools available for further understanding of ACE2 biology and for the investigation of ACE2 in the pathogenesis and treatment of COVID-19.
Source:
Nature Communications
URL: https://www.nature.com/articles/s41467-020-18880-0
Citation:
Jia, H., Yue, X. & Lazartigues, E. ACE2 mouse models: a toolbox for cardiovascular and pulmonary research. Nat Commun 11, 5165 (2020). https://doi.org/10.1038/s41467-020-18880-0
