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Biobank Multi-Modal Imaging Study of 100,000 Participants from UK

By 11th September 2020No Comments

The following study was conducted by Scientists from Nuffield Department of Population Health, University of Oxford, Oxford, UK; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK; Department of Clinical Radiology, New Royal Infirmary of Edinburgh, Edinburgh, UK; UK Biobank Coordinating Centre, Stockport, UK; Centre for Functional MRI of the Brain, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK; Research Centre for Optimal Health, University of Westminster, London, UK; Birmingham Women’s and Children’s NHS Foundation Trust, Birmingham, UK; Department of Cardiovascular Sciences and Electrical Engineering, KU Leuven, Leuven, Belgium; CISTIB Centre for Computational Imaging and Simulation Technologies in Biomedicine, Schools of Computing and Medicine, University of Leeds, Leeds, UK; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Radcliffe Department of Medicine, University of Oxford, Oxford, UK; William Harvey Research Institute, Queen Mary University of Medicine, London, UK; Department of Brain Sciences, Imperial College London and UK Dementia Research Institute, London, UK. Study is published in Nature Communications Journal as detailed below

Nature Communications; Volume 11, Article Number: 2624; (2020)

The UK Biobank Imaging Enhancement of 100,000 Participants: Rationale, Data Collection, Management and Future Directions


UK Biobank is a population-based cohort of half a million participants aged 40–69 years recruited between 2006 and 2010. In 2014, UK Biobank started the world’s largest multi-modal imaging study, with the aim of re-inviting 100,000 participants to undergo brain, cardiac and abdominal magnetic resonance imaging, dual-energy X-ray absorptiometry and carotid ultrasound. The combination of large-scale multi-modal imaging with extensive phenotypic and genetic data offers an unprecedented resource for scientists to conduct health-related research. This article provides an in-depth overview of the imaging enhancement, including the data collected, how it is managed and processed, and future directions.


Nature Communications



Littlejohns, T. J., J. Holliday, et al. (2020). “The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions.” Nature Communications 11(1): 2624.