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Experimental Pluripotent Stem Cells for Developmental Biology Research

By 25th November 2021No Comments

The following study was conducted by Scientists from Department of Neurology, Rosamund Stone Zander Translational Neuroscience Center, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA; Waisman Center, University of Wisconsin, Madison, WI, USA; Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA; Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO, USA. Study is published in Stem Cell Reports Journal – Cell Press Publishing as detailed below.

Stem Cell Reports Journal – Cell Press Publishing (2021)

Balancing Serendipity and Reproducibility: Pluripotent Stem Cells as Experimental Systems for Intellectual and Developmental Disorders

Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) and their differentiation into neural lineages is a revolutionary experimental system for studying neurological disorders, including intellectual and developmental disabilities (IDDs). However, issues related to variability and reproducibility have hindered translating preclinical findings into drug discovery. Here, we identify areas for improvement by conducting a comprehensive review of 58 research articles that utilized iPSC-derived neural cells to investigate genetically defined IDDs. Based upon these findings, we propose recommendations for best practices that can be adopted by research scientists as well as journal editors.


Stem Cell Reports Journal – Cell Press Publishing



Anderson, N.C., Chen, P.-F., Meganathan, K., Afshar Saber, W., Petersen, A.J., Bhattacharyya, A., Kroll, K.L., Sahin, M., 2021. Balancing serendipity and reproducibility: Pluripotent stem cells as experimental systems for intellectual and developmental disorders. Stem Cell Reports 16(6), 1446-1457.