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Noninvasive Light-Biodegradable Hydrogels for Gastrointestinal Therapeutic Applications

By 10th February 2020No Comments

The following study was conducted by Scientists from The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Division of Comparative Medicine, Department of Chemical Engineering, Department of Mechanical Engineering, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA. Study is published in Science Advances Journal as detailed below.

Science Advances; Jan 2020:Vol. 6, no. 3, eaay006

Light-Degradable Hydrogels as Dynamic Triggers for Gastrointestinal Applications


Triggerable materials capable of being degraded by selective stimuli stand to transform our capacity to precisely control biomedical device activity and performance while reducing the need for invasive interventions. Here, we describe the development of a modular and tunable light-triggerable hydrogel system capable of interfacing with implantable devices. We apply these materials to two applications in the gastrointestinal (GI) tract: a bariatric balloon and an esophageal stent. We demonstrate biocompatibility and on-demand triggering of the material in vitro, ex vivo, and in vivo. Moreover, we characterize performance of the system in a porcine large animal model with an accompanying ingestible LED. Light-triggerable hydrogels have the potential to be applied broadly throughout the GI tract and other anatomic areas. By demonstrating the first use of light-degradable hydrogels in vivo, we provide biomedical engineers and clinicians with a previously unavailable, safe, dynamically deliverable, and precise tool to design dynamically actuated implantable devices.


Science Advances



Raman, R., T. Hua, et al. (2020). “Light-degradable hydrogels as dynamic triggers for gastrointestinal applications.” Science Advances 6(3): eaay0065.