The following study was conducted by Scientists from Department of Pharmacology, State University of New York Upstate Medical University, Syracuse, NY, USA; Department of Surgery, State University of New York Upstate Medical University, Syracuse, NY, USA; Department of Pathology, Baylor Scott and White Medical Center, Temple, TX, USA; Sepsis Interdisciplinary Research Center, State University of New York Upstate Medical University, Syracuse, NY, USA; Upstate Cancer Center, State University of New York Upstate Medical University, Syracuse, NY, USA. Study is published in Nature Communications Journal as detailed below.
Nature Communications; Volume 11, Article Number: 3384 (2020)
A Nanotrap Improves Survival in Severe Sepsis by Attenuating Hyperinflammation
Abstract
Targeting single mediators has failed to reduce the mortality of sepsis. We developed a telodendrimer (TD) nanotrap (NT) to capture various biomolecules via multivalent, hybrid and synergistic interactions. Here, we report that the immobilization of TD-NTs in size-exclusive hydrogel resins simultaneously adsorbs septic molecules, e.g. lipopolysaccharides (LPS), cytokines and damage- or pathogen-associated molecular patterns (DAMPs/PAMPs) from blood with high efficiency (92–99%). Distinct surface charges displayed on the majority of pro-inflammatory cytokines (negative) and anti-inflammatory cytokines (positive) allow for the selective capture via TD NTs with different charge moieties. The efficacy of NT therapies in murine sepsis is both time-dependent and charge-dependent. The combination of the optimized NT therapy with a moderate antibiotic treatment results in a 100% survival in severe septic mice by controlling both infection and hyperinflammation, whereas survival are only 50–60% with the individual therapies. Cytokine analysis, inflammatory gene activation and tissue histopathology strongly support the survival benefits of treatments.
Source:
Nature Communications
URL: https://www.nature.com/articles/s41467-020-17153-0
Citation:
Shi, C., X. Wang, et al. (2020). “A nanotrap improves survival in severe sepsis by attenuating hyperinflammation.” Nature Communications 11(1): 3384.
