The following study was conducted by Scientists from Developmental Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany; Eli and Edythe Broad CIRM Center, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA. Study is published in Stem Cell Reports Journal – Cell Press Publishing as detailed below.
Stem Cell Reports Journal – Cell Press Publishing (2021)
Novel Synthetic Biology Approaches for Developmental Systems
Recently, developmental systems are investigated with increasing technological power. Still, open questions remain, especially concerning self-organization capacity and its control. Here, we present three areas where synthetic biology tools are used in top-down and bottom-up approaches for studying and constructing developmental systems. First, we discuss how synthetic biology tools can improve stem cell-based organoid models. Second, we discuss recent studies employing user-defined perturbations to study embryonic patterning in model species. Third, we present “toy models” of patterning and morphogenesis using synthetic genetic circuits in non-developmental systems. Finally, we discuss how these tools and approaches can specifically benefit the field of embryo models.
Source:
Stem Cell Reports Journal – Cell Press Publishing
URL:https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(21)00202-2
Citation:
Ho, C., Morsut, L., 2021. Novel synthetic biology approaches for developmental systems. Stem Cell Reports 16(5), 1051-1064.
