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Wearable Microfluidic Patch for Noninvasive Thermoregulatory Sweat Analysis to Monitor Human Body Physiology

By 6th September 2021No Comments

The following study was conducted by Scientists from Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA, USA; Berkeley Sensor and Actuator Center, University of California, Berkeley, CA, USA; Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. Study is published in Nature Communications Journal as detailed below.

Nature Communications; Volume 12, Article Number: 1823 (2021)

A Wearable Patch for Continuous Analysis of Thermoregulatory Sweat at Rest


The body naturally and continuously secretes sweat for thermoregulation during sedentary and routine activities at rates that can reflect underlying health conditions, including nerve damage, autonomic and metabolic disorders, and chronic stress. However, low secretion rates and evaporation pose challenges for collecting resting thermoregulatory sweat for non-invasive analysis of body physiology. Here we present wearable patches for continuous sweat monitoring at rest, using microfluidics to combat evaporation and enable selective monitoring of secretion rate. We integrate hydrophilic fillers for rapid sweat uptake into the sensing channel, reducing required sweat accumulation time towards real-time measurement. Along with sweat rate sensors, we integrate electrochemical sensors for pH, Cl−, and levodopa monitoring. We demonstrate patch functionality for dynamic sweat analysis related to routine activities, stress events, hypoglycemia-induced sweating, and Parkinson’s disease. By enabling sweat analysis compatible with sedentary, routine, and daily activities, these patches enable continuous, autonomous monitoring of body physiology at rest.


Nature Communications



Nyein, H.Y.Y., Bariya, M., Tran, B. et al. A wearable patch for continuous analysis of thermoregulatory sweat at rest. Nat Commun 12, 1823 (2021).